Here's the premise behind the mobile app Cloak: Cloak will scrub the data of your "friends" using their Instagram and Foursquare information (remember, these are things they voluntarily give out) and display them on a map using your phone's GPS. Just like that, you can completely avoid them in real time as they update their information. There's a few problems, of course. Namely, you're only going to be able to avoid people that incessantly update their every move on social media - though to be fair that seems like the perfect kind of person to excise from your life forever.
Then there's another matter entirely, that this is actually kind of a dream program for stalkers. So, uh, double-edged sword I guess?